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Ioana Sonea, PhD
Professor
G-210 Veterinary Medicine Center
East Lansing MI 48823
Phone: (517) 432-2516
E-mail: sonea@msu.edu
Education and Training
Ph.D. Veterinary Anatomy: College of Veterinary Medicine, Michigan State University, East Lansing, MI, 1993
Residency certificate in Equine Internal Medicine (1983-86), College of Veterinary Medicine, East Lansing, MI, 1986
D.M.V.: Collège de Médecine Vétérinaire, Université de Montréal, St.Hyacinthe, Québec, Canada, 1974
Research interests
I first became interested in the neural contributions to host defenses as a graduate student, interacting with the Pulmonary Laboratory at Michigan State University, in 1990. The possibility that pulmonary nerves, through the release of neuropeptides and other neurotransmitters, could affect the inflammatory and immune reactions of the lungs, was fascinating. I've maintained that interest in neuroimmune interactions ever since, and have focused on the tachykinin family of neuropeptides and their contributions to host defenses, particularly in inflammatory bowel disease (both human and veterinary). In the last few years, I have focused on the potential roles of tachykinins in the equine intestinal tract.
Selected publications
Solinger N., Sonea, I.M., Distribution of the equine neurokinin-1 receptor in equine intestinal smooth muscle. Equine Veterinary J. 2008 (Epub ahead of print).
McClure, S.R., Sonea, I.M., Evans, R.B., Yaeger, M.J., Moran, L. Evaluation of analgesia resulting from extracorporeal shock wave therapy and radial pressure wave therapy in the limbs of horses and sheep. Am J Vet Res. 2005 Oct; 66(10):1702-8.
Sonea IM, Palmer MV, Akili D, Harp JA: Treatment with neurokinin-1 receptor antagonist reduces severity of inflammatory bowel disease induced by Cryptosporidium parvum. Clinical and Diagnostic Laboratory Immunology (2002) 9(2):333-340.
Ramírez-Romero R, Brogden KA, Gallup JM, Sonea IM, Ackermann MR: Mast cell density and substance P-like immunoreactivity during the initiation and progression of lung lesions in ovine Mannheimia (Pasteurella) haemolytica pneumonia. Microbial Pathogenesis (2001) 30:325-335.
Sonea IM, Jergens AE, Sacco RE, Niyo Y, Merten E, Kauffman L, Moore PF: Flow cytometric analysis of colonic and small intestinal mucosal lymphocytes in the healthy dog. Veterinary Immunology and Immunopathology (2000) 77:103-119.
Ramírez-Romero R, Gallup JM, Sonea IM, Ackermann MR: Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep. Regulatory Peptides (2000) 91:97-106.
Sonea IM, Harkins K, Wannemuehler MJ, Jergens AE., Merten EA, Sacco RE, Cunnick J: Flow cytometric analysis of canine colonic mucosal lymphocytes obtained from endoscopic biopsies. American J Vet Res (1999) 60:346-353.
Sonea IM, Bowker RM, Robinson NE: Distribution of Substance P binding sites in equine airways. Equine Vet J. (1999) 31:238-242.
Sonea IM, Wilson DV, Bowker RM, Robinson NE: Tachykinin receptors in the equine pelvic flexure. Equine Vet J (1997) 29:306-312.
Sonea IM, Bowker RM, Robinson NE, Holland RE: Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development. Anat Embryol (1994) 190:469-477
Sonea IM, Bowker RM, Robinson NE, Broadstone RV: Substance P- and calcitonin gene-related peptide-like immunoreactive nerve fibers in lungs from adult equids. Am J Vet Res (1994) 55:1066-1074
